Wednesday, November 8, 2017

More Fst Problems

More Fst follies.


Commonly used measures such as FST and its derivatives based on gene identity probabilities do not reliably reflect difference, as they can be maximal when almost all populations are identical and very small when populations are completely distinct.

I’ve been saying this for years, citing other papers, noting the stupidity of people like J Richards of Majority Rights, who was breathlessly pontificating about minute differences in Fst values – a metric that cannot reliably determine genetic differentiation, since it is dependent upon the genetic variation within groups; it essentially is more about the apportioning of genetic variation within and between groups.

But all of this won’t stop Der Movement "activists" from using discredited metrics when it serves their purposes.