Saturday, June 30, 2018

Genes for Intelligence and TOO Doubles Down

Keeping you informed.

First read this, emphasis added:
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.
Do any of these variants differ in frequency by race or ethnicity?

It looks like TOO and MacDonald are doubling down on their direction of recent years, emphasis added:
Towards the end of the nineteenth century, as American intellectuals were coming to grips with large-scale immigration from Southern and Eastern Europe, the optimistic views of the future that were so typical of the nineteenth century were more and more difficult to defend, especially because a large number of the immigrants were (correctly) seen as politically radical and inassimilable.
Note the word “correctly.”  Thus, the position of TOO is that Southern and Eastern Europeans (which includes Tom Sunic also, I suppose, who writes for TOO) are inassimilable aliens who do not belong in America.  While I realize that is the implicit view of Der Movement, it is refreshing to see TOO so explicitly expressing an open disgust toward a significant fraction of Europe’s peoples.  That’s consistent with Amren, which praises Jews as HuWhite Men of the West, while attacking ethnies such as those hora-dancing Romanians, no men of the West they!

If anyone wonders why I stopped writing for both sites, that’s your answer.  And if that is the attitude in Der Movement, can you deny the validity of the existence of the "movement's" ethnic affirmative action program?